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. 2011 Jul 19;134(8):2339–2357. doi: 10.1093/brain/awr165

Figure 2.

Figure 2

Representative photomicrographs show the expression of angiogenesis markers in the striatum and substantia nigra pars reticulata (SNr). Only cases treated with low dose and high-dose l-dopa are shown (saline animals do not show significant alterations of these markers on either side of the brain); (Westin et al., 2006, Lindgren et al., 2009). (A, B, I and J) Epifluorescence photomicrographs of bromodeoxyuridine (BrdU)-positive cells. (C, D, K and L) Bright-field photomicrographs of nestin immunopositive vessels. (E, F, M and N) Endothelial barrier antigen (EBA) (its loss indicates blood–brain barrier malfunction). (G, H, O and P) Overview pictures of striatal and midbrain sections used to measure albumin optical density in the lateral caudate–putamen and the substantia nigra pars reticulata. Regions of interest are encircled by dashed lines. Scale bars = 100 μm (A–F and I–N), 2 mm (G, H, O and P).