Figure 9.
Parkinson’s disease (PD) dyskinetic patients have an increased expression of the immature endothelial marker, nestin on blood vessels in the basal ganglia. Representative photomicrographs of nestin expression in dyskinetic and non-dyskinetic patients in the putamen (A and B), external (ext.) and internal (int.) globus pallidus in (D and E) and (G and H), respectively). Bar graphs to the right show quantification of nestin immunopositive pixels in the putamen (C), external and internal globus pallidus (F and I, respectively) from dyskinetic patients with Parkinson’s disease (PD dyskinetic, n = 11), non-dyskinetic patients with Parkinson’s disease (PD non-dyskinetic, n = 9) and neurologically healthy controls (non-PD controls, n = 6). One-factor ANOVA followed by post hoc Student–Newman–Keul’s, P < 0.05, *versus non-Parkinson’s disease controls, #versus non-dyskinetic Parkinson’s disease. Scale bar = 25 μm.
