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Lumenal view of paclitaxel (green spacefill) bound to a straight protofilament of a microtubule as solved by Lowe et al.221 Note that paclitaxel is bound completely in the β-subunit of the dimer. The green vector shows the direction of growth of a straight protofilament, to which the tubulin–paclitaxel vector is aligned. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
