Table 3.
Association of SNP genotypes with quantitative traits affecting glucose homeostasis in NG Controls (un-stratified for obesity)‡
| rs1387153 | CC | CT | TT | Effect β (95% CI) | P value |
|---|---|---|---|---|---|
| Total (N) | 363 | 479 | 131 | -- | -- |
| FBG (mg/dL)€ | 95.0 (93.5 – 96.5) | 94.9 (93.7 – 96.2) | 96.2 (93.4 – 99.2) | 0.01 (−0.01 – 0.02) | 0.338 |
| 2h Glucose (mg/dL) | 105.8 (102.8 – 108.8) | 104.6 (101.5 – 107.7) | 105.8 (101.5 – 110.3) | 0.00 (−0.03 – 0.02) | 0.841 |
| Fasting Insulin(μIU/mL) | 7.5 (6.6 – 8.5) | 7.6 (6.8 – 8.4) | 7.2 (5.7 – 9.2) | −0.01 (−0.13 – 0.10) | 0.844 |
| HOMA IR* | 1.6 (1.4 – 1.8) | 1.7 (1.5 – 1.9) | 1.8 (1.3 – 2.3) | 0.04 (−0.08 – 0.16) | 0.538 |
| HOMA B£ | 84.5 (72.5 – 98.5) | 86.6 (76.5 – 98.2) | 82.2 (60.8 – 111.2) | −0.01 (−0.15 – 0.12) | 0.813 |
| rs1374645† | CC | CT + TT | Effect β (95% CI) | P value | |
| Total (N) | 869 | 118 + 2 | -- | -- | -- |
| FBG (mg/dL) | 95.4 (94.5 – 96.4) | 93.4 (90.9 – 96.1) | -- | −0.02 (−0.05 – 0.01) | 0.169 |
| 2h Glucose (mg/dL) | 106.0 (103.9 – 108.1) | 99.7 (94.9 – 104.8) | -- | −0.06 (−0.12 – −0.01) | 0.026 |
| Fasting Insulin(μIU/mL) | 7.5 (6.9 – 8.2) | 7.5 (6.1 – 9.2) | -- | −0.03 (−0.26 – 0.21) | 0.826 |
| Homa-IR | 1.7 (1.5 – 1.8) | 1.6 (1.3 – 2.0) | -- | −0.01 (−0.25 – 0.23) | 0.921 |
| Homa B | 84.5 (76.7 – 93.2) | 88.6 (68.4 – 114.8) | -- | 0.00 (−0.25 – 0.27) | 0.935 |
| rs10830963 | CC | CG | GG | Effect β (95% CI) | P value |
| Total (N) | 393 | 445 | 163 | -- | -- |
| FBG (mg/dL) | 95.2 (93.8 – 96.7) | 94.6 (93.3 – 96.0) | 95.8 (93.7 – 98.0) | 0.00 (−0.01 – 0.02) | 0.586 |
| 2h Glucose (mg/dL) | 106.4 (103.6 – 109.3) | 105.3 (102.2 – 108.5) | 102.3 (97.9 – 107.0) | −0.01 (−0.04 – 0.01) | 0.367 |
| Fasting Insulin(μIU/mL) | 7.3 (6.4 – 8.2) | 7.6 (6.8 – 8.5) | 8.4 (6.9 – 10.1) | 0.08 (−0.03 – 0.19) | 0.151 |
| Homa-IR | 1.6 (1.4 – 1.8) | 1.7 (1.5 – 1.9) | 2.0 (1.6 – 2.5) | 0.13 (0.02 – 0.24) | 0.026 |
| Homa B | 80.3 (69.3 – 92.9) | 88.2 (77.1 – 101.0) | 95.0 (75.4 – 119.5) | 0.05 (−0.05 – 0.20) | 0.232 |
€
fasting blood glucose;
*
homeostasis model assessment for insulin resistance;
£
homeostasis model assessment for β cell function;
†
homozygous minor allele carriers were analyzed combined with heterozygotes because of small number;
‡
Analysis was performed using age, BMI, and gender as covariates in multiple linear regression.