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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Eur J Cell Biol. 2011 Apr 14;91(1):78–85. doi: 10.1016/j.ejcb.2011.01.015

Figure 1. Domain structure of and signalling by the RLR family members.

Figure 1

(A) RIG-I, MDA5 and LGP2 share a C-terminal RD domain and an SF2-type ATPase domain. In addition RIG-I and MDA5 have two N-termial CARD domains required for signalling via IPS1 that are absent in LGP2.

(B) Signalling in the RLR pathway is initiated by binding of RNA to the respective receptor (RIG-I or MDA5). LGP2 may assist ligand recognition or inhibit signalling under certain circumstances. Binding of one of the receptor proteins to the mitochondrial adapter IPS1 leads to the activation of transcription factors of the IRF and NF-kB families. This ultimately leads to the production of interferons and inflammatory cytokines.