Table 1.
SPR results for the 24 confirmed selective fragment hits (structures in Fig. 3)
| Compound | Mw (Da) | K d (mM) | % TRmax |
|---|---|---|---|
| 1 | 220.2 | 1.80 | 122 |
| 2 | 211.3 | 3.87 | 137 |
| 3 | 185.2 | 1.27 | 221 |
| 4 | 240.0 | 0.78 | 216 |
| 5 | 194.6 | 1.59 | 365 |
| 6 | 210.0 | 1.38 | 434 |
| 7 | 208.3 | >10 | N/A |
| 8 | 214.3 | 2.21 | 333 |
| 9 | 234.0 | 1.97 | 232 |
| 10 | 235.3 | 1.84 | 147 |
| 11 | 246.3 | >10 | 0 |
| 12 | 200.0 | 4.89 | 493 |
| 13 | 243.4 | 2.45 | 312 |
| 14 | 230.0 | >10 | N/A |
| 15 | 208.2 | 0.22 | 198 |
| 16 | 218.2 | 0.79 | 126 |
| 17 | 238.0 | 7.13 | 624 |
| 18 | 236.2 | 1.54 | 255 |
| 19 | 212.2 | 2.34 | 447 |
| 20 | 245.3 | 3.19 | 288 |
| 21 | 244.3 | 0.48 | 125 |
| 22 | 237.6 | >10 | N/A |
| 23 | 187.2 | >10 | N/A |
| 24 | 244.3 | 1.9 | 170 |