Table 3.
Property summary of compound leads
| Hit | Molecular Weight |
Solubilitya (μg/mL) |
Solubility (μM) |
|---|---|---|---|
| 9 | 377.436 | 1.4 | 3.6 |
| 10 | 305.370 | 1.1 | 3.5 |
| 14 | 478.606 | 0.9 | 1.9 |
| 15 | 349.426 | 19.1 | 54.7 |
| 27 | 451.313 | 1.4 | 3.2 |
Solubility of compound in PBS was determined by measuring the chemiluminescence of total nitrogen contents (www.aniliza.com).