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. Author manuscript; available in PMC: 2011 Aug 14.
Published in final edited form as: J Immunol. 2007 Jul 15;179(2):1282–1291. doi: 10.4049/jimmunol.179.2.1282

FIGURE 6.

FIGURE 6

Transmission of Th1- or Th2-biased maternal Abs to offspring was determined by the adjuvant used for immunization. Females were immunized with OVA-Al(OH)3 or OVA-CFA and challenged for 7 days with 1% aerosolized OVA (daily exposure time 60 min). Six weeks later, females were bred with naive C57BL/6J males and pregnant mice were re-exposed to aerosolized OVA on E11–17 of pregnancy. Serum was collected from naive 2-wk-old pups (1 wk before weaning) and concentrations of OVA-specific Igs were measured by ELISA. OVA-specific Igs were absent from serum of pups born to naive C57BL/6J mothers (data not shown). Bar labels refer to conditions of maternal sensitization. Results represent the mean ± SE from three to four determinations per group. Each determination was made using sera from individual mice for IgG1 and IgG2a or sera combined from two mice for IgE and IgA. Statistical analysis could not be performed for OVA-specific IgE or IgA as analysis of sera from progeny of OVA-Al(OH)3 immune mothers was a pooled sample from two mice. *, p ≤ 0.05 when compared between groups.