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Concentration–response curves for coronary flow (A), heart rate (B), and left ventricular developed pressure (C) for NECA in isolated perfused hearts from WT apolipoprotein E–knockout mice, and APOE-HFD.
Notes: *Significant difference from WT; #significant difference from APOE.
Abbreviations: APOE, apolipoprotein E; APOE-HFD, APOE fed high-fat diet; HR, heart rate; LVDP, left ventricular developed pressure; NECA, 5′-N-ethylcarboxamide adenosine; WT, wild type.
