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Concentration–response curves for changes in isometric tension produced by NECA in isolated aorta from WT, APOE, and APOE-HFD (A). Responses to 1 µM acetylcholine after preconstriction with 0.1 µM phenylnephrine in aortas from WT, APOE, and APOE-HFD (B).
Notes: *Significant difference from WT; #significant difference from APOE.
Abbreviations: APOE, apolipoprotein E; APOE-HFD, APOE fed high-fat diet; NECA, 5′-N-ethylcarboxamide adenosine; WT, wild type.
