TABLE 3.

Factors predictive of disease-specific survival

Variable	Univariate analysis			Multivariable analysis
	Hazard ratio	95% CI	P-Value	Hazard ratio	95% CI	P-Value
Age (years)			0.005			0.003
<50	1.00			1.00
50–69	1.16	0.96–1.41		1.19	0.81–1.79
≥70	1.44	1.37–1.54		1.57	1.44–1.75
Sex			0.09			0.61
Male	1.00			1.00
Female	0.92	0.84–1.01		1.06	0.85–1.92
Decade of diagnosis			0.91
1970 s	0.96	0.72–1.27
1980 s	1.08	0.88–1.31
1990 s	1.00	0.84–1.17
2000 s	1.00
Race			0.50
White	1.00
Black	1.01	0.64–1.60
Asian/Pacific Islander	0.79	0.55–1.13
American Indian or Alaska Native	1.76	0.44–7.06
Primary site			<0.001			0.001
Oral cavity	0.65	0.52–0.81		0.71	0.45–1.11
Oropharynx	1.29	0.87–1.91		0.46	0.16–1.33
Nasal cavity	0.74	0.62–0.88		0.75	0.48–1.17
Nasopharynx	1.13	0.84–1.52		2.29	1.19–4.42
Paranasal sinus	1.00			1.00
Size (cm)			<0.001			0.004
≤2	1.00			1.00
2–4	1.83	1.79–2.13		1.56	1.48–1.61
>4	1.69	1.33–2.17		1.59	1.15–2.17
Lymph node status			<0.001			0.004
Negative	1.00			1.00
Positive	1.41	1.19–1.64		1.59	1.16–2.13
Distant metastases			<0.001			<0.001
None	1.00			1.00
Present	1.75	1.56–1.96		1.92	1.43–2.63
Treatment modality			<0.001			0.41
Surgery	1.00			1.00
Surgery + radiation	1.16	1.09–1.16		0.84	0.82–1.28
Radiation	1.56	1.35–1.72		0.78	0.77–1.18
None	2.38	2.09–2.59		0.93	0.69–1.85