TABLE 3.
Association between body size and promoter methylation of genes in postmenopausal women: case-case comparisons
| Methylation of ≥1 of 3 genes | Unmethylated | OR (95% CI)1 | |
| n | n | ||
| BMI | |||
| <25 kg/m2 | 107 | 57 | 1.0 |
| 25–29 kg/m2 | 127 | 61 | 1.12 (0.70, 1.78) |
| ≥30 kg/m2 | 143 | 71 | 1.02 (0.64, 1.61) |
| P-trend | — | — | 0.98 |
| Waist-to-hip ratio | |||
| <0.78 | 70 | 52 | 1.0 |
| 0.78–0.81 | 73 | 36 | 1.41 (0.82, 2.44) |
| 0.82–0.87 | 100 | 50 | 1.37 (0.82, 2.27) |
| ≥0.88 | 125 | 48 | 1.85 (1.10, 3.11) |
| P-trend | — | — | 0.02 |
| Abdominal height | |||
| <17.83 cm | 40 | 24 | 1.0 |
| 17.83–19.94 cm | 62 | 30 | 1.10 (0.55, 2.21) |
| 19.95–22.74 cm | 82 | 35 | 1.35 (0.69, 2.65) |
| ≥22.75 cm | 90 | 45 | 0.98 (0.51, 1.91) |
| P-trend | — | — | 0.96 |
| Weight change (from age 20 y to 1 y before the study) | |||
| ≤4.1 kg | 82 | 38 | 1.02 |
| 4.2–8.0 kg | 89 | 49 | 0.79 (0.46, 1.35) |
| 8.1–12.4 kg | 109 | 55 | 0.83 (0.49, 1.40) |
| >12.4 kg | 97 | 47 | 0.91 (0.53, 1.58) |
| P-trend | — | — | 0.83 |
1
Unless noted otherwise, values are ORs (95% CIs) that were computed by unconditional logistic regression and adjusted for age, race, education, age at menarche, age at first birth, age at menopause, family history of breast cancer in first-degree relatives, history of benign breast disease, energy, alcohol drinking status, smoking status, and estrogen receptor status.
2
Additionally adjusted for BMI for weight-change analyses.