Table 2.

highest and lowest D-scores

a) FS indels
Rank	Gene	Essential	Mutation at base	D
1	SMD1	YES	2	0.987
2	RPL8A	NO	224	0.985
3	TFB3	YES	92	0.963
4	RAD34	NO	154	0.963
5	ERG25	YES	214	0.928
b) NMs
74	TIF5	YES	1213	0.002
73	CRT10	NO	2869	0.002
72	COX19	NO	292	0.001
71	SWI4	NO	3256	0.001
70	HYM1	YES	1193	0.001

A sample of ranked genes in terms of their information loss score D. (a) The top 5 genes with FS indels with highest scores (b) The bottom 5 genes with NMs with lowest scores.