Table 1.
Baseline Characteristics of Patients With Chronic Hepatitis C Virus Genotype 2 or 3
| Genotype 2 (n = 427) | Genotype 3 (n = 505) | P valuea | |
|---|---|---|---|
| Sex, n (%) | .004 | ||
| Male | 228 (53) | 317 (63) | |
| Female | 199 (47) | 188 (37) | |
|
| |||
| Race, n (%) | <.001 | ||
| Caucasian | 211 (49) | 377 (75) | |
| Asian | 187 (44) | 116 (23) | |
| Black/African heritage | 13 (3) | 4 (1) | |
| Other | 16 (4) | 8 (2) | |
|
| |||
| Age | |||
| Mean ± SD, y | 49.3 ± 10.8 | 40.4 ±10.0 | <.001 |
| <45 y, n (%) | 128 (30) | 317 (63) | <.001 |
| ≥45 y, n (%) | 299 (70) | 188 (37) | |
|
| |||
| Weight | |||
| Mean ± SD, kg | 72.8 ± 17.9 | 75.8 ± 17.1 | .01 |
| <75 kg, n (%) | 269 (63) | 263 (52) | <.001 |
| ≥75 kg, n (%) | 158 (37) | 242 (48) | |
|
| |||
| BMI | |||
| Mean ± SD, kg/m2 | 26.1 ± 5.0 | 26.0 ± 4.9 | .79 |
| <30 kg/m2, n (%) | 340 (80) | 410 (81) | .55 |
| ≥30 kg/m2, n (%) | 87 (20) | 95 (19) | |
|
| |||
| HOMA-IR | n =362 | n = 402 | |
| Mean ± SD | 3.0 ± 2.8 | 3.4 ± 4.5 | .12 |
| Insulin resistant, n (%)b | 178 (49) | 209 (52) | .44 |
|
| |||
| Steatosis, n (%)c | 115 (27) | 232 (46) | <.001 |
|
| |||
| ALT, n (%) | |||
| >1.5x ULN | 187 (44) | 285 (56) | <.001 |
| ≥1.5x ULN | 240 (56) | 220 (44) | |
|
| |||
| GGT, n (%) | |||
| ≤ULN | 328 (77) | 363 (72) | .087 |
| >ULN | 99 (23) | 142 (28) | |
|
| |||
| HCV RNA | |||
| Mean ± SD, log10 IU/mL | 6.0 ± 0.9 | 6.0 ± 0.9 | .96 |
| ≥400,000 IU/mL, n (%) | 302 (71) | 347 (69) | .51 |
| <400,000 IU/mL, n (%) | 125 (29) | 158 (31) | |
|
| |||
| Fibrosis | n =424 | n = 498 | |
| F3–4, n (%) | 50 (12) | 54 (11) | .65 |
| F0–2, n (%) | 374 (88) | 444 (89) | |
ALT, alanine transaminase; BMI, body mass index; f, fibrosis stage; GGT, γ-glutamyl transpeptidase; HCV, hepatitis C virus; HOMA-IR, homeostasis model of assessment–insulin resistance; SD, standard deviation; ULN, upper limit of normal.
a
2-sided P value for comparison of genotypes obtained from Pearson chi-square or t test.
b
Defined as HOMA-IR >2.
c
Defined as fat grade >5% on baseline biopsy or HOMA-IR score >4.5 and triglyceride level >180 mg/dL if biopsy data were missing.