Voltage-gated as well as voltage-independent currents are modulated by group I mGluR agonists. A, Voltage protocol and evoked currents before and after application of s-DHPG. B, s-DHPG-dependent current obtained by subtraction. C, Current–voltage curves for currents during the downward ramp before and after application of s-DHPG. D, Current–voltage curve for s-DHPG-dependent current during the downward ramp. Synaptic transmission was blocked by SR95531, DNQX, and CPP. Na current was blocked by QX-314.