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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: Thromb Haemost. 2009 Oct;102(4):623–633. doi: 10.1160/TH09-04-0238

Figure 7. Comparison of amino acid sequence between human and bovine factor Va heavy chain.

Figure 7

The heavy chain comprises of the A1 domain that spans residues 1 to 303, followed by a thirteen residue connecting region, followed by the A2 domain that spans residues 317 to 656 in human and residues 317 to 660 in bovine, and finally the carboxy-terminal end region that spans residues 657 to 709 in human and residues 661 to 713 in bovine. The hirudin-like peptide D(Y/S)DYQ (695–699 in human and 699–703 in bovine) is located in this carboxy-terminal region. Human Factor V sequence pubmed accession #AAB59532; Bovine Factor V sequence pubmed accession #AAA30512.