Table 1.

Patient characteristics

Characteristic
Median age, y (range)	54.5 (23-60)
Sex, M:F	16:14
Median WBC, ×109/L (range)	14.4 (1.5-211)
Median platelet count, ×109/L (range)	57 (9-175)
Cytogenetics, no. subjects (%)*
Intermediate, diploid, abn(12p),† +8,† +21	15 (50)
Adverse complex, −7/7q, 11q23,‡ t(6;9)	13 (43)
Unknown add(18p), t(2:11)(q31;p15)	2 (7)
FLT3-ITD, no. subjects (%)	4 (13)
Antecedent hematologic disorder, no. subjects (%)	8 (27)
WBC, no. subjects (%)
> 100 000	5 (17)
> 50 000	8 (27)
≥ 1 Adverse molecular feature, no. subjects (%)§	17 (57)
≥ 1 Adverse feature, no. subjects (%)¶	25 (83)

The majority of subjects had at least 1 adverse prognostic feature.

^*ECOG/SWOG criterion.²

^†abn(12p), +8 are considered adverse risk by CALGB.¹

^‡t(11;19)(q23;p13.1), t(10;11)(p12;q23).

^§Adverse karyotype or FLT3-ITD.

^¶Adverse molecular features or antecedent hematologic disorder, age ≥ 55, WBC > 50 000.