Table 6.

Decitabine-induced change in DNA methylation

Cell population locus	BMCD34P	BMCD34N	BMMC Change in methylation (%), significance	PBMC	GRANS
HIST1H2AA	−32, P = .001	−16, P = .075	−30, P = .005	−25, P = .020	8, P = .67
LINE1	−19, P = .068	−24, P = .012	−46, P = .012	−28, P = .001	−14, P = .11

For each specimen type, DNA methylation at the HIST1H2AA locus and LINE1 repeat class was compared before (screening) and after (post-priming) decitabine priming. The negative -fold change reflects the reduction in DNA methylation induced by decitabine. Statistical significance (P) of the -fold change was calculated using a one-sided Student t test for the paired specimens.