Table 2.

Asymmetric isomerization of 8a to 9a by a cinchona alkaloid bearing a 6' hydrogen bonding donor^a

entry	catalyst	T(°C)	Time	conv.(%)b	ee(%)b
1	1a	rt	10min	20	67
2	1b	rt	10min	16	60
3	1c	rt	10min	12	74
4	3a	rt	10min	5	60
5	3b	rt	10min	5	63
6	6	rt	10min	55	64
7	Q-7	rt	10min	33	84
8	QD-7	rt	10min	57	−86
9	QD-7	−20	24h	36	−92
10	QD-7	−20	72h	80	−90

^aUnless noted, reactions were run with 0.05 mmol of 8a in 0.05 mL of CH₂Cl₂ with 10 mol% catalyst. See supporting information for details.

^bDetermined by HPLC analysis.