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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: Handb Exp Pharmacol. 2009;(194):31–74. doi: 10.1007/978-3-540-79090-7_2

Fig. 5.

Fig. 5

Instillation of protamine sulfate in to the bladder can sensitize mechanosensitive afferent fiber to urinary bladder distension (UBD). The left column illustrates responses of a pelvic nerve afferent fiber to 0.1, 0.2, and 0.4 ml of distension, respectively. Thirty minutes following the instillation of protamine sulfate (1 mgml−1) the fiber exhibited greater response (right column) to UBD. Note that the fibers exhibited markedly higher response at lower volume (0.3 ml) of distension