Table 3.
Genotypic Characteristics of Methicillin-Susceptible Staphylococcus aureus Bloodstream Isolates From Patients With Endocarditis According to Geographic Region
| Genes, no. (%) | North America n = 26 (23) | Europe & Middle East n = 76 (68) | Australia & New Zealand n = 10 (9) | P value |
| Adhesins | ||||
| fnbA | 26 (100) | 76 (100.0) | 8 (80) | .007a |
| fnbB | 8 (30.8) | 5 (6.8) | 2 (20) | .006a |
| clfA | 26 (100) | 75 (98.7) | 10 (100) | 1.000 |
| clfB | 26 (100) | 76 (100.0) | 10 (100) | … |
| cna | 18 (69.2) | 67 (88.2) | 7 (70) | .041 |
| spa | 24 (92.3) | 75 (98.7) | 10 (100) | .241 |
| sdrC | 14 (53.8) | 33 (43.4) | 3 (30) | .385 |
| sdrD | 17 (65.4) | 45 (59.2) | 8 (80) | .450 |
| sdrE | 15 (57.7) | 37 (48.7) | 7 (70) | .389 |
| bbp | 24 (92.3) | 67 (88.2) | 8 (80) | .516 |
| ebpS | 26 (100.0) | 76 (100.0) | 10 (100.0) | … |
| map/eap | 15 (57.7) | 40 (52.6) | 8 (80) | .290 |
| Toxins | ||||
| eta | 8 (30.8) | 17 (22.4) | 2 (20) | .683 |
| etb | 0 (0.0) | 5 (6.6) | 0 (0) | .581 |
| tst | 23 (88.5) | 73 (96.1) | 9 (90) | .217 |
| sea | 16 (61.5) | 50 (65.8) | 6 (60) | .860 |
| seb | 2 (7.7) | 0 (0.0) | 2 (20) | .004a |
| sec | 9 (34.6) | 16 (21.1) | 4 (40) | .224 |
| sed | 9 (34.6) | 12 (15.8) | 3 (30) | .098 |
| see | 0 (0.0) | 28 (36.8) | 3 (30) | <.001a |
| seg | 16 (61.5) | 57 (75) | 5 (50) | .163 |
| seh | 4 (15.4) | 8 (10.5) | 1 (10) | .800 |
| sei | 24 (92.3) | 66 (86.8) | 10 (100) | .626 |
| sej | 2 (7.7) | 1 (1.3) | 1 (10) | .118 |
| pvl | 0 (0.0) | 20 (26.3) | 1 (10) | .003a |
| hlg | 26 (100) | 76 (100) | 10 (100) | … |
| Other putative virulence genes | ||||
| efb | 26 (100) | 75 (98.7) | 10 (100) | 1.000 |
| icaA | 26 (100) | 68 (89.5) | 10 (100) | .182 |
| chp | 24 (92.3) | 61 (80.3) | 7 (70) | .213 |
| v8 | 17 (65.4) | 40 (52.6) | 8 (80) | .211 |
| AGR group | ||||
| agr I | 8 (30.8) | 24 (31.6) | 4 (40) | .894 |
| agr II | 9 (34.6) | 26 (34.2) | 4 (40) | … |
| Agr III | 9 (34.6) | 21 (27.6) | 2 (20) | … |
| Agr IV | 0 (0.0) | 5 (6.6) | 0 (0) | … |
NOTE. Two of 114 patients were excluded from geographical analysis because they originated from South America.
a
Statistically significant after adjustment for multiple comparisons using a false discovery rate of 10%.