Table 6.
Genotypic Characteristics of Geographically Matched Methicillin-Susceptible Staphylococcus aureus Isolates From Patients With Endocarditis or Soft Tissue Infection
| Genes, no. (%) | Infective endocarditis (n = 114) | Soft tissue infection (n = 114) | P value |
| Adhesins | |||
| fnbA | 112 (98.2) | 110 (100) | .498 |
| fnbB | 17 (15.2) | 16 (14) | 1.000 |
| clfA | 113 (99.1) | 114 (100) | 1.000 |
| clfB | 114 (100) | 32 (28.1) | <.0001a |
| cna | 93 (81.6) | 61 (53.5) | <.0001a |
| spa | 111 (97.4) | 114 (100.0) | .247 |
| sdrC | 51 (44.7) | 35 (30.7) | .040 |
| sdrD | 71 (62.3) | 72 (63.2) | 1.000 |
| sdrE | 60 (52.6) | 65 (57) | .595 |
| bbp | 101 (88.6) | 104 (91.2) | .661 |
| ebpS | 114 (100) | 114 (100) | … |
| map/eap | 65 (57) | 20 (17.5) | <.0001a |
| Toxins | |||
| eta | 27 (23.7) | 19 (16.7) | .248 |
| etb | 5 (4.4) | 0 (0.0) | .060 |
| tst | 107 (93.9) | 37 (32.5) | <.0001a |
| sea | 74 (64.9) | 36 (31.6) | <.0001a |
| seb | 4 (3.5) | 9 (7.9) | .253 |
| sec | 29 (25.4) | 28 (24.6) | 1.000 |
| sed | 24 (21.1) | 6 (5.3) | <.001a |
| see | 31 (27.2) | 4 (3.5) | <.0001a |
| seg | 80 (70.2) | 66 (57.9) | .073 |
| seh | 13 (11.4) | 7 (6.1) | .241 |
| sei | 102 (89.5) | 61 (53.5) | <.0001a |
| sej | 4 (3.5) | 6 (5.3) | .748 |
| pvl | 22 (19.3) | 31 (27.2) | .209 |
| hlg | 114 (100) | 114 (100) | … |
| Other putative virulence genes | |||
| efb | 113 (99.1) | 111 (97.4) | .622 |
| icaA | 106 (93) | 111 (97.4) | .215 |
| chp | 94 (82.5) | 78 (68.4) | .021 |
| V8 | 66 (57.9) | 73 (64) | .415 |
| AGR group | .003a | ||
| agr I | 36 (31.6) | 57 (50) | … |
| agr II | 40 (35.1) | 20 (17.5) | … |
| agr III | 33 (28.9) | 27 (23.7) | … |
| agr IV | 5 (4.4) | 10 (8.8) | … |
NOTE. a Statistically significant after adjustment for multiple comparisons using a false discovery rate of 10%.