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. 2011 Aug 15;6(8):e23253. doi: 10.1371/journal.pone.0023253

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Khalifé et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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At E9.5, PrP expression was observed in endothelial cells of blood vessels (a), including dorsal aortas (b, c) and in the developing heart with, as shown in this figure, a very intense signal observed in the sinus venosus. The saturated signal visible here (asterisk) is artefactual. HSV: horn of the sinus venosus. At E9.5, PrP expression in the nervous system is mainly detected in the lateral part of the neural tube (NT), the mantle zone (arrow): this zone is formed by cells undergoing differentiation that have migrated from the medial part of the neural tube where cells continue to divide (progressively during development, PrP staining in neural tube increases as the mantle zone thickened; our unpublished data).