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. 2011 Aug 15;6(8):e23538. doi: 10.1371/journal.pone.0023538

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Eleore et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A, B) Evolution of fEPSPs evoked in the PFC (A) and in the CA1 area (B) by paired-pulse stimulation of reuniens nucleus before and after two HFS sessions. Each animal was presented with two HFS sessions (see shaded areas) each consisting of five 200 Hz, 100 ms trains of pulses at a rate of 1/s. This protocol was presented six times, at intervals of 1 min. The 100 µs, square, biphasic pulses used to evoke LTP were applied at the same intensity used for the single pulse presented following HFS presentation. The evolution of LTP was checked using a pair of pulses (1st, black circles; 2nd, white circles) with an interstimulus interval of 40 ms. Recording was carried out for 72 h. Note that fEPSP amplitudes evoked by the 1st and the 2nd pulses reached values below baseline following the two HFS sessions for both synapses. *, P<0.05 for fEPSPs evoked by the 1st pulse; #, P<0.05 for fEPSPs evoked by the 2nd pulse.