Table 3.
Effect of Concomitant Antibiotics (CAs) by Risk and Number of Classes on Clinical Cure Rates
| Clinical cure | CA use during treatment phase (days 1–10) |
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| CA risk categorya |
No. of CA antibiotic classesb |
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| Low | High | 1 | ≥2 | |
| % (proportion) of subjects | 96.67 (29/30) | 81.19 (82/101) | 88.36 (129/146) | 71.74 (33/46) |
| Difference (95% CI) | −15.48 (−1.94 to −24.39) | −16.62 (−30.77 to −3.24) | ||
| P | .04 | .007 | ||
NOTE. CI, confidence interval.
a
See Table 1 for explanation of risk categories. There were no significant differences by risk category or number of classes for endpoints of recurrence and global cure. There were no significant differences for high risk vs low/medium risk combined for any endpoint.
b
There were 19 antibiotic classes (see Supplementary table). All cephalosporins were combined into 1 class, and all penicillins and penicillin combinations were combined into 1 class.