Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dominant-negative Stat3 inhibits transformation by p110α-H1047R. Chicken embryonic fibroblasts were transfected with RCAS(B)-Stat3DB, a dominant-negative, DNA-binding defective form of Stat3 or RCAS(B) as an empty vector control. These cells were then superinfected with dilutions of Avian sarcoma virus 17, expressing (A) v-jun or (B) RCAS(A)-p110α-H1047R. Focus formation induced by p110α-H1047R was strongly inhibited by Stat3DB.
