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(A) LFM-A13, a Tec kinase inhibitor, blocks Stat3 phosphorylation. 10T1/2-H1047R cells were treated with 20 μM LFM-A13 for 0, 1, 6, 24, or 48 h as indicated. Cells were lysed and analyzed by Western blotting using the indicated antibodies. (B) LFM-A13 inhibits transformation by RCAS(A)-p110α-H1047R. CEF were infected with RCAS(A)-p110α-H1047R and either not treated or treated with varying concentrations of LFM-A13. Treatment with 20 μM LFM-A13 is shown.
