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Dominant-negative Stat3 (Stat3DB) reduces the efficiency of oncogenic transformation by all class I PI3K isoforms
| Oncoprotein | EOT* |
| p110α-H1047R | 0.16 ± 0.05 |
| p110α-E545K | 0.17 ± 0.05 |
| p110β | 0.33 ± 0.10 |
| p110γ | 0.12 ± 0.03 |
| p110δ | 0.05 ± 0.01 |
| v-Src | 0.19 ± 0.06 |
*EOT, efficiency of transformation = focus count in Stat3DB-transfected CEF over focus count in CEF transfected with empty vector.
