Figure 2. Ectopic expression of GPRC fragment induces tumor angiogenesis and growth in MC-1 cells.
A. Expression of GPRC in MC-1 cells significantly enhanced tumor growth.
B. Expression of GPRC induced tumor angiogenesis. Tumor sections from MC-1(EV) and MC-1(GPRC) cells were stained with the anti-PECAM antibody (green) and the anti-GPRC (red).
C. Blood vessel densities were significantly higher in tumors from the MC-1(GPRC) cells than those from the MC-1(EV) cells. **: p < 0.001, Student’s t-test.