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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Cancer Res. 2011 Jul 1;71(16):5558–5568. doi: 10.1158/0008-5472.CAN-10-4543

Figure 4.

Figure 4

GPR56 regulates melanoma progression by inhibiting VEGF production through the STP segment.

A. Expression of GPR56 significantly inhibited production of VEGF in the media of MC-1 cells, but expression of ΔSTP-GPR56 enhanced it.

B. Expression of GPRC in MC-1 cells significantly increased production of VEGF.

C. Expression of ΔSTP-GPR56 induced VEGF production in multiple melanoma cell lines.

D. FcGPRN-1 protein inhibited VEGF production from MC-1(GPRC) cells. FcLA protein was used as a control.

E. VEGF mRNA was knocked down by shRNAs in MC-1(ΔSTP-GPR56) cells.

F. Knocking down of VEGF in MC-1(ΔSTP-GPR56) cells led to a reduction in tumor growth.