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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Cancer Res. 2011 Jul 1;71(16):5558–5568. doi: 10.1158/0008-5472.CAN-10-4543

Figure 7. Model of GPR56 function in VEGF production by melanoma cells.

Figure 7

We hypothesize that the free GPRC fragment of GPR56 represents a basal/constitutive “on” state to induce the activation of PKCα, VEGF production, angiogenesis, and melanoma progression. The binding of full-length GPRN switches GPRC to an “off” state and inhibits those processes. The binding of ΔSTP-GPRN, however, activates it and promotes melanoma progression.