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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cell Signal. 2011 Jun 25;23(11):1794–1805. doi: 10.1016/j.cellsig.2011.06.014

Figure 9. Suggested architecture of PRL-R signaling network with potential routes of MAPK activation in breast cancer cells.

Figure 9

Solid lines with arrows show the activation or phosphorylation of proteins. Dotted lines indicate the formation of phosphatidylinositol-trisphosphate (PIP3) by PI3-kinase. Solid lines with circular ends represent protein-protein and protein-lipid interactions. Thick solid lines show prevailing routes of ERK1/2 activation.