Fig. 3.

Summary of interactions determining cytoskeletal rearrangements and cell motility in C85 cells during maintenance phase of methotrexte-induced senescence. The interactions of the “outside-in” signaling direction are marked. ECM, integrins and focal adhesion molecules are shown as a complex. Listed are selected molecules upregulated in senescent C85 cells whose functional assignment was performed in IPA software. ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, GPCR G-protein-coupled receptor, MET met proto-oncogene, MYL12A/B myosin regulatory light chain, NRP1 neuropilin 1, PAK2/6 p21-activated kinase 2/6, PLXNB1 plexin B1, Rho ras homologue gene family. Other abbreviations are used as in Fig. 2. Corresponding microarray data are presented in Table S6