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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Pharmacol Biochem Behav. 2011 Jun 29;99(4):671–675. doi: 10.1016/j.pbb.2011.06.025

Figure 3. Withdrawal jumping induced by naltrexone and 6β-naltrexol following 1, 3 or 6 days of morphine treatment.

Figure 3

Mice were implanted s.c. with a morphine pellet (25 mg) for 1 (A) or 3 days (B). Other mice were implanted s.c. with one morphine pellet (25 mg) for 3 days and then an additional morphine pellet (25 mg) for 3 more days for total of 6 days of treatment (C). At the end of treatment, mice (N=5–30/dose) were injected s.c. with naltrexone (0.0125–2 mg/kg) or 6β-naltrexol (1.5–140 mg/kg) and immediately observed for withdrawal jumping for 15 min.