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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Expert Opin Ther Targets. 2011 Jul 1;15(9):1085–1097. doi: 10.1517/14728222.2011.594043

Figure 2.

Figure 2

Activation of nuclear receptors PPARɣ and LXR induce the expression of genes necessary for insulin sensitization and lipid metabolism. Interestingly, activation of PPARɣ induces LXRα and LXRα induces expression of PPARɣ, driving a positive-feedback loop (A). RXR activation induces the activation of their permissive heterodimer binding partners, resulting the expression of both PPARɣ and LXRα target genes (B).