Figure 2.
Activation of nuclear receptors PPARɣ and LXR induce the expression of genes necessary for insulin sensitization and lipid metabolism. Interestingly, activation of PPARɣ induces LXRα and LXRα induces expression of PPARɣ, driving a positive-feedback loop (A). RXR activation induces the activation of their permissive heterodimer binding partners, resulting the expression of both PPARɣ and LXRα target genes (B).