Fig. 6.

Effect of the folate and/or ABT-737 pretreatment on the etoposide-induced cell death of PCTC-LGG. a Characterization of 20 LGG. 12/20 LGG present similar characteristics than the Ntv-a/PDGF cells, i.e., a high PDGFrβ activity (higher or equal to the median value), a low level of DNA methylation (lower to the median value), a low DEVDase activity (lower to the median value), a high level of phospho-Bad (higher or equal to the median value), and the unmethylation of the bcl-w and bcl-xl genes. b Two primary cultured tumor cells obtained from LGG (PCTC-LGG) were treated with folate, ABT-737, and/or epotoside (50 μg/ml), and cell death was estimated by using Trypan blue method