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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2011 Jan 13;51(5):1027–1034. doi: 10.1016/j.freeradbiomed.2011.01.006

Table 1.

Summary of the large, multicenter randomized trials of inhaled NO in term newborns with hypoxemic respiratory failure and/or PPHN, showing the effect of iNO on ECMO utilization and mortality. Table adapted from (85), * denotes significant reduction (p < 0.05).

% ECMO % Mortality
n Initial OI Control iNO Control iNO
NINOS (86) 235 44 55 39* 17 14
Roberts (87) 58 44.4 71 40* 7 7
Clark (88) 248 39 65 48* 8 7
Davidson (89) 155 24.7 34 22 2 8
Konduri (32) 299 19.2 12 10 9 7