Table.
Mean age- and sex-adjusted weighted genetic risk score (GRS) (95% confidence interval) by parental history of diabetes in the PPP-Botnia and Framingham Offspring Studies (FOS)
| PPP-Botnia | Framingham Offspring | |||
|---|---|---|---|---|
| Number of parents with diabetes | n | Mean GRS | n | Mean GRS |
| 0 | 3142 | 16.8 (16.8–16.9) | 1438 | 16.6 (16.5–16.8) |
| 1 | 965 | 16.9 (16.8–17.1) | 363 | 16.8 (16.6–17.0) |
| 2 | 112 | 17.1 (16.8–17.4) | 35 | 17.3 (16.6–18.1) |
| ptrend | 0.032 | 0.072 | ||
Ptrend corresponds to the regression coefficients for number of parents with diabetes as a predictor of GRS in generalized (PPP-Botnia) and mixed-effects (FOS) linear models. GRS consists of the same 33 single-nucleotide polymorphisms (SNPs) in both cohorts except rs2237895 in PPP-Botnia and rs2237892 in FOS.