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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Apr 23;21(17):5045–5049. doi: 10.1016/j.bmcl.2011.04.068

Figure 3.

Figure 3

Proposed binding of sialyl-T antigen analogs to MAG. a) Homology model of MAG constructed from the solved structures siglecs-1, -5 and -7 depicting the binding of an analog of disialyl-T antigen (13c). b) Model highlighting the spatial relationship of the α2–3 sialic acid bound to the conserved arginine (R118), the αThr and the 9-N-fluoro-benzolamide on the α2–6 sialic acid (see Supplementary material for analysis of glycan torsion angles; Figure S1). c) Inset showing the steric clash of the 9-N-fluoro-benzolamide on the α2–3 sialic acid with the N-acetyl groups of the GalNAc and αThr.