. Author manuscript; available in PMC: 2012 Aug 15.

Published in final edited form as: Chem Res Toxicol. 2011 Jul 20;24(8):1327–1337. doi: 10.1021/tx200218u

Table 3.

Inhibition of P450 1A1-, 1A2, and 1B1-Dependent EROD Activities by Organoselenium Compounds

	IC₅₀ for inhibition of EROD activity (µM)
P450	BSC	o-XSC	m-XSC	p-XSC
P450 1A1	0.45 ± 0.038	0.11 ± 0.021	0.10 ± 0.013	0.26 ± 0.031
P450 1A2	1.3 ± 0.22	0.39 ± 0.042	0.20 ± 0.021	0.63 ± 0.059
P450 1B1	0.27 ± 0.031	0.14 ± 0.027	0.13 ± 0.011	0.16 ± 0.009

IC₅₀ values were obtained by measuring EROD activities catalyzed by P450 1A1, 1A2, and 1B1. IC₅₀ values represent means ± SE.