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Inhibition of P450 2A6- and 2A13-Dependent Coumarin 7-Hydroxylation Activities by Organoselenium Compounds
| IC50 for inhibition of coumarin 7-hydroxylation activity (µM) |
||||
|---|---|---|---|---|
| P450 | BSC | o-XSC | m-XSC | p-XSC |
| P450 2A6 | 4.3 ± 0.36 | 2.7 ± 0.34 | 2.4 ± 0.19 | 6.2 ± 0.55 |
| P450 2A13 | 1.2 ± 0.19 | 1.2 ± 0.13 | 0.22 ± 0.031 | 1.4 ± 0.21 |
IC50 values were obtained by measuring coumarin 7-hydroxylation activities catalyzed by P450 2A6 and 2A13. IC50 values represent means ± SE.
