Table 3.
Percentage bias and bias on a logarithmic scale (95% confidence interval) for eGFR calculated using the CKD-EPI equation and MDRD equation with mGFR by iothalamate renal clearance in different populations
| eGFR range (ml/min/1.73 m2) | Equation | Potential Kidney Donors | Postnephrectomy Kidney Donors | Native CKD | Kidney Recipients | Other Organ Recipients |
|---|---|---|---|---|---|---|
| Percentage bias | ||||||
| overall | CKD-EPI | −8% (−10%, −7%) | −7% (−11%, −4%) | 6% (4%, 8%) | 8% (6%, 10%) | 9% (7%, 12%) |
| MDRD | −18% (−19%, −16%) | −15% (−18%, −12%) | 3% (2%, 5%) | 1% (0%, 3%) | 3% (1%, 6%) | |
| >90 | CKD-EPI | −3% (−5%, −1%) | −4% (−34%, 26%) | 16% (11%, 21%) | 26% (19%, 34%) | 18% (13%, 24%) |
| MDRD | −8% (−11%, −5%) | −17% (−49%, 14%) | 18% (11%, 25%) | 36% (22%, 51%) | 18% (11%, 29%)) | |
| 60 to 89 | CKD-EPI | −13% (−15%, −11%) | 2% (−4%, 8%) | 7% (3%, 11%) | 14% (11%, 16%) | 11% (7%, 14%) |
| MDRD | −20% (−22%, −19%) | −3% (−12%, 6%) | 1% (−3%, 5%) | 6% (3%, 9%) | 3% (0%, 7%) | |
| 45 to 59 | CKD-EPI | −16% (−25%, −7%) | −13% (−17%, −8%) | 7% (2%, 13%) | 3% (1%, 5%) | 9% (3%, 15%) |
| MDRD | −25% (−30%, −21%) | −18% (−22%, −15%) | −1% (−4%, 3%) | −2% (−4%, 0%) | 3% (−2%, 8%) | |
| 30 to 44 | CKD-EPI | −15% (−20%, −10%) | 5% (1%, 8%) | 4% (1%, 7%) | 4% (−1%, 9%) | |
| MDRD | −19% (−23%, −15%) | 2% (−2%, 6%) | −2% (−5%, 1%) | −1% (−5%, 4%) | ||
| 15 to 29 | CKD-EPI | 5% (1%, 8%) | 11% (3%, 19%) | 1% (−7%, 9%) | ||
| MDRD | 5% (2%, 9%) | 5% (−2%, 11%) | 3% (−7%, 13%) | |||
| <15 | CKD-EPI | 0% (−7%, 7%) | 7% (−10%, 24%) | 7% (−29%, 43%) | ||
| MDRD | 2% (−5%, 9%) | 3% (−13%, 20%) | −6% (−31%, 19%) | |||
| Bias on a logarithmic scale | ||||||
| overall | CKD-EPI | −10% (−11%, −9%) | −9% (−12%, −5%) | 1% (−1%, 2%) | 4% (3%, 6%) | 5% (3, 7%) |
| MDRD | −19% (−20%,−18%) | −16% (−19%, −13%) | −2% (−3%, −1%) | −2% (−3%, −1%) | −1% (−3%, 1%) | |
| >90 | CKD-EPI | −4% (−6%, −2%) | −7% (−32%, 29%) | 11% (7%, 15%) | 23% (16%, 30%) | 15% (11%, 20%) |
| MDRD | −9% (−12%, −6%) | −18% (−45%, 22%) | 12% (7%, 18%) | 31% (19%, 44%) | 15% (9%, 22%) | |
| 60 to 89 | CKD-EPI | −14% (−16%, −13%) | 1% (−5%, 7%) | 2% (1%, 5%) | 11% (8%, 13%) | 7% (4%, 11%) |
| MDRD | −22% (−23%, −20%) | −5% (−14%, 4%) | −3% (−6%, −1%) | 3% (1%, 6%) | 0% (−3%, 3%) | |
| 45 to 59 | CKD-EPI | −17% (−25%, −9%) | −14% (−18%, −9%) | 1% (−2%, 4%) | 0% (−2%, 2%) | 4% (0%, 7%) |
| MDRD | −26% (−21%, −22%) | −19% (−23%, −16%) | −5% (−8%, −2%) | −5% (−7%, −3%) | −2% (−5%, 1%) | |
| 30 to 44 | CKD-EPI | −15% (−20%, −10%) | −1% (−3%, 2%) | 0% (−2%, 3%) | 0% (−4%, 4%) | |
| MDRD | −19% (−23%, −15%) | −3% (−6%, −1%) | −6% (−8%, −3%) | −5% (−8%, −1%) | ||
| 15 to 29 | CKD-EPI | −1% (−3%, 2%) | 5% (−2%, 12%) | −4% (−11%, 4%) | ||
| MDRD | −1% (−3%, 2%) | −1% (−6%, 5%) | −3% (−10%, 6%) | |||
| <15 | CKD-EPI | −7% (−11%, −3%) | 3% (−11%, 20%) | 1% (−29%, 43%) | ||
| MDRD | −6% (−10%, −1%) | 0% (−14%, 15%) | −10% (−33%, 22%) |
The percentage bias was calculated as follows: {Σ [(eGFR − mGFR)/mGFR × 100%]}/n. The percentage bias on a logarithmic scale was calculated as follows: exp[Σ (log eGFR − log mGFR)/n] − 1. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; MDRD, Modification of Diet in Renal Disease; eGFR, estimated GFR; mGFR, measured GFR.