Table 1.

Various polymeric vectors utilized for in vivo ocular gene delivery.

Polymeric carrier	Delivery site	Target tissue	Model	Year	Ref.
PEG–PLL	Intravitreal and subretinal injection	RPE cells and photoreceptor population	Mouse	2006	[55]
Hyaluronan–chitosan nanoparticle	Topical application	Corneal and conjunctival cells	Rabbit	2008	[28]
PLGA nanoparticles	Intravitreal injection	RPE cells	Rat	2005	[98]
PEG–PLA microparticles	Subretinal injection	Photoreceptor layer	Rat	2010	[102]
ODN–PEI complexes	Intravitreal injection	Superficial and inner retinal layers	Rat	2006	[84]
PEO–PPO–PEO micelles	Topical application	Anterior and posterior segment tissues	Mouse and rabbit	2007	[27]
Dehydrated plasmid–PEI complexes	corneal stromal pocket	Cornea	Rats	2005	[85]

ODN–PEI: Oligonucleotide–polyethylenimine; PEG–PLA: Polyethylene glycol–polylactic acid; PEG–PLL: Polyethylene glycol–poly L-lysine; PEO–PPO–PEO: Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide); PLGA: Poly(lactide-co-glycolide); RPE: Retinal pigment epithelium.