Skip to main content
. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Expert Rev Endocrinol Metab. 2011 May 1;6(3):359–369. doi: 10.1586/eem.11.25

Figure 2. Progesterone receptor-B, but not progesterone receptor-A, and estrogen receptor-α participate in membrane-tethered protein complexes capable of rapidly activating c-Src and MAPKs.

Figure 2

Progesterone/PR and estrogen/ER transactivate EGFR and/or ErbB2; phosphorylated steroid hormone receptors and signaling molecules, including protein kinases and surface receptors, enter the nucleus and participate in transcription complexes at selected gene promoters.

E2: Estradiol; EGFR: EGF receptor; ER: Estrogen receptor; P: Phosphorylation; P4: Progesterone; PR: Progesterone receptor; Shc: Src homology domain II containing.