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. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: J R Stat Soc Ser C Appl Stat. 2011 Aug 1;60(4):541–557. doi: 10.1111/j.1467-9876.2011.00765.x

Left panel: Posterior distribution of the hyperparameter $τ_{s}^{2}$ for 50 simulated gene sets. Sets 1–4 have 20, 10, 5, and 2 significant genes respectively. Sets 5–50 contain no significant genes. Right panel: Posterior distribution of β_sg for individual genes in Set 2, where the first 10 genes are significantly upregulated (the constant 1 is added to the expression values for the treatment group). The remaining 10 genes in this set are non-significant (β_sg = 0).

Left panel: Posterior distribution of the hyperparameter $τ_{s}^{2}$ for 50 simulated gene sets. Sets 1–4 have 20, 10, 5, and 2 significant genes respectively. Sets 5–50 contain no significant genes. Right panel: Posterior distribution of β_sg for individual genes in Set 2, where the first 10 genes are significantly upregulated (the constant 1 is added to the expression values for the treatment group). The remaining 10 genes in this set are non-significant (β_sg = 0).