Table 1. Rhythm and aging phenotypes of mice with mutations in genes contributing to the transcriptional activator complex.

	ClockΔ19/Δ19	Clock−/−	Npas2m/m	Clock−/−;Npas2m/m	Bmal1−/−
Circadian Behavior:
Rhythmic in DD?	Varies [123,141-144]	Yes [4, 117]	Yes [4, 145]	No [4]	No [106]
Period length	Long [~28 hr] to AR	Slightly shorter	Slightly shorter	N/A - Arrhythmic	N/A - Arrhythmic
Ex vivo Rhythms:
SCN slice	Arrhythmic [124]	Rhythmic [4, 118]	Rhythmic [118]	Arrhythmic [118]	Arrhythmic [115, 124; but see 147]
Peripheral tissues	Arrhythmic [115, 124]	Arrhythmic [118]	Rhythmic [118]	Arrhythmic [118]	Arrhythmic [115, 147]
Aging Phenotypes
Lifespan	Reduced (Female) Normal (Male) [49]	Reduced (Both) [1]	Seems OK (Both) [our unpublished]	Reduced (Both) [116]	Reduced (Both) [50, 107, 111]
Body weight	Increased [148]	Normal [1]	N.D.	Reduced [our unpublished]	Reduced [50]
Organ weights	Normal [148]	Normal [1]	N.D.	N.D.	Most Reduced [50]
Cataract incidence	N.D.	Increased [1]	N.D.	N.D.	Increased [50]
Dermatitis	N.D.	Increased [1]	N.D.	N.D.	Normal [48]
Ectopic calcification	No [our unpublished]	No [116]	No [116]	Yes [116]	Yes [108, 112]
Reproduction	Modest decrease [121, 122, 150-153]	Modest decrease [our unpublished]	Seems OK [4, 145, our unpublished]	Sterile [our unpublished]	Sterile [109, 110]
Tumor incidence	Normal [49]	N.D.	N.D.	N.D.	N.D.
Response to Irradiation
Lifespan	Reduced (Female) Normal (Male) [49]	N.D.	N.D.	N.D.	N.D.
Body weight	Reduced (Both) [49]	N.D.	N.D.	N.D.	N.D.
Organ weights	Some Reduced [F]; Normal (Male) [49]	N.D.	N.D.	N.D.	N.D.
Cataract incidence	Increased (Both) [49]	N.D.	N.D.	N.D.	N.D.
Dermatitis	N.D.	N.D.	N.D.	N.D.	N.D.
Tumor incidence	Normal [49]	N.D.	N.D.	N.D.	N.D.