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. 2011 Aug 16;6(8):e23652. doi: 10.1371/journal.pone.0023652

Figure 2. Influence of LKM512 administration on intestinal environment.

Figure 2

(A) Appearance of large intestine obtained from LKM512 (upper) and control (bottom) mice at week 45. (B) 16S rRNA gene expression in the predominant intestinal bacterial group at week 45. 16S rRNA gene expression in the bacterial group was normalized to total bacterial 16S rRNA expression. Expression in control and younger mice is shown relative to the expression in the LKM512 mice. (C) Fecal SPD (right) and SPM (left) concentrations in each group. (D) The concentration of SCFA in each group. (E) Fecal mutagenicity stimulated with S-9 mix and without S-9 mix in each group. In (B) – (E), data are represented as mean ± SEM. *P<0.05, **P<0.01, ***P<0.001.