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. 2011 Aug 16;6(8):e23652. doi: 10.1371/journal.pone.0023652

Figure 3. Influences of LKM512 administration on colonic barrier function.

Figure 3

(A) Histology of proximal colon samples from mice treated with LKM512 (left) or PBS (control; right). The samples shown in the upper panels are stained with HE, while those in the bottom panels are stained with PAS. [Scale bars, 500 µm (HE), 100 µm (PAS).] (B) Colon permeability at week 25, as indicated by the urinary lactulose/rhamnose ratio. (C) Colonic gene expression of Muc2, Muc3, Occludin, and ZO-1 in all treatment groups and in younger mice. Data are represented as mean ± SEM. *P<0.05.