Table 1.
Similarity between modules identified by SSIM and four major prion subnetworks
| Module | Genes in the module | PrPSc accumulation | Microglial activation | Neuronal cell death | Synaptic degeneration |
|---|---|---|---|---|---|
| 1 | 21 | 16 (76%) | 5 (24%) | 2 (10%) | 0 (0%) |
| 2 | 27 | 7 (26%) | 21 (78%) | 1 (4%) | 1 (4%) |
| 3 | 15 | 12 (80%) | 0 (0%) | 3 (20%) | 0 (0%) |
| 4 | 37 | 5 (14%) | 5 (14%) | 10 (27%) | 20 (54%) |
| 5 | 42 | 16 (38%) | 14 (33%) | 13 (31%) | 4 (10%) |
| 6 | 33 | 1 (3%) | 1 (3%) | 12 (36%) | 24 (73%) |
| 7 | 34 | 5 (15%) | 22 (65%) | 9 (26%) | 2 (6%) |
| 8 | 37 | 6 (16%) | 0 (0%) | 9 (24%) | 24 (65%) |
| 9 | 49 | 2 (4%) | 7 (14%) | 37 (76%) | 6 (12%) |
| 10 | 41 | 19 (46%) | 19 (46%) | 8 (20%) | 2 (5%) |
| 11 | 39 | 7 (18%) | 29 (74%) | 5 (13%) | 4 (10%) |
| 12 | 43 | 2 (5%) | 13 (30%) | 18 (42%) | 12 (28%) |
| 13 | 46 | 19 (41%) | 38 (83%) | 2 (4%) | 0 (0%) |
| 14 | 57 | 5 (9%) | 36 (63%) | 17 (30%) | 7 (12%) |
| 15 | 67 | 5 (7%) | 2 (3%) | 23 (34%) | 49 (73%) |
| 16 | 60 | 5 (8%) | 0 (0%) | 2 (3%) | 54 (90%) |
For each module, the number and the proportion of genes corresponding to prion subnetworks are shown. Since some genes are involved in multiple subnetworks, the row-wise summation of proportions may exceed 100%.