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. 2011 Aug 16;6(8):e23410. doi: 10.1371/journal.pone.0023410

Figure 5. Expression patterns of Hox10, Hox11 and Foxd1 in the early nephrogenic cord.

Figure 5

At E11.5, the Hox10 genes (A) exhibit a more anterior boundary of expression in dissected urogentital mesenchyme compared to Hox11 in control mice (Compare arrowheads in A and C). By E13.5, Hox10 (B) and Hoxa11eGFP (D) are both expressed in the nephrogenic cap mesenchyme, but Hox10 genes (B') are additionally expressed in the cortical stroma cells (black arrow), whereas Hox11 (D') is expressed in the renal vesicles but not in the cortical stroma (white arrow). (E) At E11.5, Foxd1 expression forms a highly concentrated cap-like pattern localized just anterior to the metanephric kidney. (F–G) As development progresses, these Foxd1-expressing cells are observed in progressively posterior positions (F, G). Panels (B–B') and (D–D') show light microscopy and fluorescent images of the same section, respectively. In situ hybridization analyses for Hox10 was performed using probes to all three paralogs (Hoxa10, Hoxc10, Hoxd10).